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Xanax (Alprazolam) is an intermediate-acting anxiolytic benzodiazepine derivative drug used to treat panic disorders, anxiety disorders such as anxiety disorder or social phobia.

  • Other names: Alprazolam
  • Active component: Alprazolam
  • Strength: 0.5mg, 1mg, 2mg
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Information

Alprazolam - part of the group of anxiolytics, exhibits hypnosedative properties, helps to eliminate convulsive syndrome in various neurological disorders. Alprazolam is an anxiolytic drug characterized by hypnotic, pronounced anticonvulsant, as well as antidepressant action. Under the influence of alprazolam, an increase in the inhibitory effect of γ-aminobutyric acid in the central nervous system is observed, the susceptibility of GABA receptors to this mediator due to a specific stimulating effect on benzodiazepine receptors of the GABA-benzodiazepine-chlorionophore complex.

During the use of alprazolam, muscle relaxation is recorded, the frequency decreases onset of the convulsive syndrome.

The drug has a moderate hypnotic effect, promotes rapid falling asleep, improves the quality of sleep, reduces the number of awakenings at night. Mechanism of action is the ability to weaken the activity of cells of the reticular formation, located directly in the brain stem and reduce the effect vegetative, emotional, as well as motor factors that negatively affect sleep.

While taking the medication, most people experienced a decrease in the severity anxiety and fear, emotional stress was eliminated, general well-being in neuroses of obsessive-compulsive disorders.

The drug has almost no effect on the cardiovascular system and the respiratory system in completely healthy individuals.

Indications for use

Short-term therapy with Alprazolam is indicated in case of moderate or severe disorders in the work of the National Assembly (increased anxiety, a feeling of constant fear and anxiety) associated with depression.

The drug is not intended for the treatment of neurological disorders in adults and children, caused by stress in everyday life.

Alprazolam can be used to treat people with panic attacks disorders, sleep disturbance, developed withdrawal syndrome (including the one observed in patients with alcoholism and drug addiction).

Pharmacokinetics

After taking the pills, rapid absorption of alprazolam in the gastrointestinal tract is recorded, the highest plasma concentrations are reached after 1-2 hours. Bioavailability index is about 80%. With an increase in the dosage of drugs, plasma concentrations active substance increase proportionally. Approximately 80% of the accepted dosage of alprazolam comes into contact with plasma proteins. Active ingredient penetrates the blood-brain and placental barrier, it determined in breast milk. Equilibrium plasma concentrations observed 2-3 days after the start of treatment.

Metabolic transformations occur in liver cells, while there is formation of an α-hydroxyl metabolite. It is excreted with the participation of the renal system in the form of compounds with glucuronic acid. The duration of the half-life is not more than 16 hours. A drug practically does not accumulate in body tissues.

Dosage

The drug is recommended for oral use, they drink pills, regardless of food intake. Usually the daily dosage should be applied in several doses (2 or 3). The duration of treatment therapy is determined on an individual basis. the tolerability of the active substance, the general condition of the patient is taken into account. In depending on the observed therapeutic effect, the doctor can adjust dose of drugs.

For adults with depression, panic disorders, you should take the drug at a dosage of 0.1-0.2 mg of drugs from 2 to 3 times during the day. after two weeks treatment, a gradual increase in dosage is possible (first increase the evening dose, later in the morning). It is recommended to use a daily dose of 3-6 mg.

Elderly patients or when the body is depleted is prescribed to receive no more 0.25 mg of drugs three times a day. An increase in this dose is possible under strict medical supervision.

With increased anxiety, poor sleep, excessive anxiety, usually prescribed to drink 0.7-1.5 mg of drugs per day. It is possible to increase the dose to 3-4.5 mg.

The highest daily dosage of the drug is 10 mg.

Long-term use of Alprazolam may be prescribed, treatment may continue for 3 months. It is necessary to cancel drugs slowly, preferably lower the dosage by 500 mcg every 3 days. over the next 2-6 weeks. In the event of an abrupt end Taking pills may cause the so-called withdrawal syndrome. When accounting the general condition of the patient and the observed individual responses to lowering dosage, the duration of the withdrawal period may increase.

When choosing the optimal dosage, it should be borne in mind that in persons who were taking psychotropic drugs, there is a better response to medicine with alprazolam (usually prescribed low therapeutic doses to achieve the expected therapeutic effect) than those who previously took anxiolytics, and antidepressants.

Use during pregnancy and breastfeeding

The drug is not prescribed for pregnant and lactating women. Taking medication before delivery can cause respiratory depression. functions, a sharp decrease in muscle tone, the development of arterial hypotension, decrease in body temperature, as well as a weakening of the sucking reflex in infants (the occurrence of sluggish sucking syndrome).

Contraindications and precautions

It is not recommended to start treatment with Alprazolam if:

  • Presence of excessive sensitivity to the main and additional constituents
  • Lactose intolerance
  • Diagnosis of respiratory failure
  • Serious pathologies of the liver and kidney system
  • Glaucoma
  • Poisoning with narcotic substances, hypnotic drugs or psychotropic drugs.

Alprazolam and alcohol are incompatible, since alcohol can provoke the development side effects and reduce the effectiveness of the treatment. The drug is not used in pediatrics. During the course of treatment, it is not recommended to engage in work that requires increased concentration of attention, as well as a high speed of psychomotor reactions.

Consult your doctor before you decide to buy xanax online ! Take any medications only after your doctor has prescribed treatment for you.

Side effects

At the initial stages of treatment, lethargy, drowsiness may be felt, there is dizziness, impaired concentration, drug dependence, inhibition of psychomotor reactions. The likelihood of a side effect symptoms are much higher in elderly patients. The following side effects may occur:

  • Nervous system: sleep disturbance, tremor, memory impairment, the occurrence of depressive conditions, confusion; in rare cases, such reactions are possible - aggression, anxiety, hallucinations, speech disorder
  • Gastrointestinal tract, metabolism: dryness of the mucous membranes in the mouth, weight loss, development anorexia, the appearance of heartburn, the development of liver pathologies, the appearance of signs jaundice, nausea, stool disorder
  • Sense organs: change in taste perception, decreased vision
  • Other: development of dystonia, decrease or increase in libido, delay urination, dysmenorrhea, myasthenia gravis, impaired functioning of the renal systems, enuresis

Withdrawal syndrome

In case of a sharp decrease in the dosage of drugs or a complete cessation of taking Alprazolam may cause withdrawal syndrome:

  • Severe dystrophy
  • Insomnia
  • Spasm of the muscles of the internal organs
  • Frequent vomiting
  • Increased sweating
  • Convulsive syndrome
  • Tremor.

Overdose

An overdose is manifested in a decrease in reflexes, impaired coordination of movements, severe drowsiness, in some cases, death is not excluded (when taken with other benzodiazepines, alcohol).

Cross-drug interactions

It is possible to use the drug Alprazolam with antidepressants by persons suffering from endogenous depression.

Mutual strengthening of influence is observed at the combined reception with narcotic painkillers, neuroleptics, anticonvulsants and hypnotic drugs, muscle relaxants of the central exposure, as well as ethyl alcohol.

With the simultaneous use of drugs based on inhibitors of microsomal oxidation increases the likelihood of toxic effects of alprazolam.

There may be a decrease in the therapeutic efficacy of treatment with simultaneous reception with inducers of microsomal oxidation.

Under the influence of alprazolam, an increase in the plasma concentration of imipramine is observed.

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